Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review

In this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched to access cases of SPA in salivary glands. One hundred and thirty cases of SPA were found across 6...

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Published in:Head & neck 2023-09, Vol.45 (9), p.2449-2457
Main Authors: Carvalho Kimura, Talita, Lima‐Souza, Reydson Alcides, Scarini, João Figueira, Lavareze, Luccas, Egal, Erika Said Abu, Altemani, Albina, Mariano, Fernanda Viviane
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Adenoma
Oral cancer
Parotid gland
Point mutation
Salivary gland
salivary gland neoplasms
sclerosing polycystic adenoma
sclerosing polycystic adenosis
Stroma
systematic review
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Summary:In this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched to access cases of SPA in salivary glands. One hundred and thirty cases of SPA were found across 61 selected articles. SPA affected mainly the parotid gland of adults with a mean age of 44.6 years old, with a slight preference for females. The lesion was usually presented as a painless firm mass with a long period of evolution. Histologically, they are well‐delimitated lesions composed of acinar and ductal elements with a variety of cytomorphologic features surrounded by a densely collagenized stroma. PI3K was the most common gene mutation related to SPA. SPA is a benign condition that mainly affects the parotid gland of female patients and it is usually treated by surgical resection with a good prognosis.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.27435