Hyaluronic acid-quercetin pendant drug conjugate for wound healing applications

In this study, a simple approach was used for the synthesis of a water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate to evaluate its potential wound-healing properties. The HA-Q conjugation was confirmed by Fourier-transform infrared spectroscopy (FTIR), ultraviolet–visible spectro...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-06, Vol.240, p.124336-124336, Article 124336
Main Authors: Rao, Kummara Madhusudana, Kim, Eunbi, Kim, Hyeon Jin, Uthappa, Uluvangada Thammaiah, Han, Sung Soo
Format: Article
Language:English
Subjects:
Antioxidants - chemistry
biocompatibility
cell movement
drugs
fibroblasts
Fourier transform infrared spectroscopy
Hyaluronic acid
Hyaluronic Acid - chemistry
nuclear magnetic resonance spectroscopy
Pendant conjugate
Quercetin
Quercetin - chemistry
Quercetin - pharmacology
ultraviolet-visible spectroscopy
Water
water solubility
Wound Healing
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Summary:In this study, a simple approach was used for the synthesis of a water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate to evaluate its potential wound-healing properties. The HA-Q conjugation was confirmed by Fourier-transform infrared spectroscopy (FTIR), ultraviolet–visible spectrophotometry (UV–Vis), and nuclear magnetic resonance (NMR) spectroscopy techniques. To produce the HA-Q, quercetin was conjugated on the HA backbone to the extent of 44.7 %. The HA-Q conjugate was soluble in water and a solution with a concentration of 20 mg/ml was prepared. The conjugate exhibited good biocompatibility and supported the growth and cell migration of skin fibroblast cells. HA-Q presented improved radical scavenging capacity compared to quercetin (Q) alone. The overall results confirmed the potential role of HA-Q in wound healing applications.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.124336