Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

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Published in:Molecular and Cellular Biology 2013-06, Vol.33 (12), p.2436-2446
Main Authors: Lau, Alexandria, Zheng, Yi, Tao, Shasha, Wang, Huihui, Whitman, Samantha A., White, Eileen, Zhang, Donna D.
Format: Article
Language:English
Subjects:
3T3 Cells
Adaptor Proteins, Signal Transducing - drug effects
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Animals
arsenic
Arsenic - pharmacology
Arsenic - toxicity
autophagosomes
autophagy
Autophagy - drug effects
carcinogenicity
Cell Line
Cell Survival
cell viability
chemoprevention
Cytoskeletal Proteins - drug effects
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
Enzyme Activation
Epithelium - drug effects
Epithelium - metabolism
HEK293 Cells
Humans
hydroquinone
Hydroquinones - pharmacology
Isothiocyanates
Kelch-Like ECH-Associated Protein 1
Lung - drug effects
Lung - metabolism
Mice
Microtubule-Associated Proteins - metabolism
Neoplasms - chemically induced
NF-E2-Related Factor 2 - drug effects
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
RNA Interference
RNA, Small Interfering
Signal Transduction
sulforaphane
Thiocyanates - pharmacology
Transcription Factor TFIIH
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
ISSN:0270-7306
1098-5549
1098-5549
DOI:10.1128/MCB.01748-12