Profile of the intestinal microbiota of patients with cystic fibrosis: A systematic review

Cystic fibrosis (CF) is a multisystem disease that can compromise several human body organs. The autosomal recessive genetic disorder is caused by different mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, responsible for chloride ion transport across apical membrane...

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Bibliographic Details
Published in:Clinical nutrition ESPEN 2023-06, Vol.55, p.400-406
Main Authors: de Souza Furtado, Juliano, de Almeida Brasiel, Poliana Guiomar, Luquetti, Sheila Cristina Potente Dutra
Format: Article
Language:English
Subjects:
Bacteria
bacterial communities
bicarbonates
Bifidobacterium
Biomarkers
chlorides
clinical nutrition
Cystic fibrosis
Cystic Fibrosis - microbiology
cystic fibrosis transmembrane conductance regulator
Enterococcus
epithelium
Gastrointestinal Microbiome
genes
genus
Humans
intestinal microorganisms
intestines
meta-analysis
Microbiota
Mutation
Roseburia
secretion
Streptococcus
Systematic review
Veillonella
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Summary:Cystic fibrosis (CF) is a multisystem disease that can compromise several human body organs. The autosomal recessive genetic disorder is caused by different mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, responsible for chloride ion transport across apical membranes of epithelial cells in tissues and bicarbonate secretion. In this study, we provide a systematic review of the profile of the intestinal microbiota of cystic fibrosis individuals. The review was conducted according to Preferred Items of Reports for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. PubMed/MEDLINE and Scopus databases were searched for relevant articles until Jully 2022. Eighteen studies (1304 participants) met the inclusion criteria. The quality and bias was assessed using the Methodological index for non-randomized studies (MINORS) tool, with the majority of the studies indicating medium to high quality. Results showed significant changes in the composition of the intestinal microbiota of the individuals with CF compared with healthy controls, with increased of Enterococcus, Veillonella, and Streptococcus, and decreased of Bifidobacterium, Roseburia, and Alistipes genus. The intestinal bacterial community of CF patients was marked by a reduction in its richness and diversity. The systematic review suggests a change in the intestinal microbiota of CF individuals, characterized by a reduction in microbial diversity and abundance of some bacterial markers.
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2023.04.008