Association between estimated pulse wave velocity and risk of diabetes: A large sample size cohort study

Estimated pulse wave velocity (ePWV) measurements have good agreement with PWV measurements. However, the relationship between ePWV and the risk of new-onset diabetes remains unclear. Therefore, this study aimed to investigate whether ePWV was associated with new-onset diabetes. Based on a secondary...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2023-09, Vol.33 (9), p.1716-1724
Main Authors: Bao, Wei, Chen, Chunwei, Chen, Chengwen, Zhang, Xia, Miao, Hao, Zhao, Xinliang, Huang, Shuo, Li, Chengzong
Format: Article
Language:English
Subjects:
Adult
Arterial stiffness
Cohort Studies
Cohort study
Diabetes
Diabetes Mellitus - diagnosis
Diabetes Mellitus - epidemiology
ePWV
Female
Humans
Male
Pulse Wave Analysis
Risk Factors
Sample Size
Vascular Stiffness
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Summary:Estimated pulse wave velocity (ePWV) measurements have good agreement with PWV measurements. However, the relationship between ePWV and the risk of new-onset diabetes remains unclear. Therefore, this study aimed to investigate whether ePWV was associated with new-onset diabetes. Based on a secondary analysis of the Chinese Rich Health Care Group's cohort study, 211,809 participants who met the criteria were enrolled and divided into four groups based on the ePWV quartiles. Diabetes events are of interest as a result of the study. Over a mean follow-up of 3.12 years, 3000 male (1.41%) and 1173 female (0.55%) patients were diagnosed with new-onset diabetes. The cumulative incidence curves based on quartile subgroups showed that the Q4 group had a significantly higher overall incidence of diabetes than the other subgroups. A multivariate Cox regression analysis showed that ePWV was an independent predictor of new-onset diabetes (hazard ratio, 1.233; 95% confidence interval, 1.198–1.269; P 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2023.05.032