Selective Cross-Dehydrogenative Coupling of Various Acyclic Enamides with Heteroarenes via Rh(III)-Catalyzed C–H Activation

The developed methodology describes an efficient Rh­(III)-catalyzed oxidative C–H/C–H cross-coupling between acyclic enamides and heteroarenes. This cross dehydrogenative coupling (CDC) reaction offers advantages, including excellent regioselectivity and stereoselectivity, good functional group comp...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2023-07, Vol.25 (28), p.5262-5267
Main Authors: Li, Xiaolan, Luo, Haiqing, Song, Ruixin, Zhang, Yuting, Gong, Xian, Cai, Hu, Luo, Xuzhong
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The developed methodology describes an efficient Rh­(III)-catalyzed oxidative C–H/C–H cross-coupling between acyclic enamides and heteroarenes. This cross dehydrogenative coupling (CDC) reaction offers advantages, including excellent regioselectivity and stereoselectivity, good functional group compatibility, and a broad substrate scope. Mechanistically, Rh­(III)-catalyzed β–C­(sp2)–H activation of acyclic enamides is proposed to be the critical step.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c01786