Ameliorative effect of Stevia rebaudiana Bertoni on sperm parameters, in vitro fertilization, and early embryo development in a streptozotocin-induced mouse model of diabetes

Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant effect on fertilization success and embryo development....

Full description

Saved in:
Bibliographic Details
Published in:Zygote (Cambridge) 2023-10, Vol.31 (5), p.1-482
Main Authors: Abdi, Mahdad, Alizadeh, Fathemeh, Daneshi, Erfan, Abouzaripour, Morteza, Fathi, Fardin, Rahimi, Kaveh
Format: Article
Language:English
Subjects:
Animals
Blood
Blood glucose
Blood levels
Diabetes
Diabetes mellitus
Embryos
Fertility
Gametocytes
Hyperglycemia
In vitro fertilization
Insulin resistance
Leaves
Mathematical models
Metabolic disorders
Metabolism
Morphology
Motility
Oocytes
Parameters
Reproductive disorders
Reproductive system
Sexual behavior
Sperm
Stevia
Stevia rebaudiana
Streptozocin
Sugar
Testes
Testosterone
Weight
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant effect on fertilization success and embryo development. The current study aimed to investigate the effect of hydroalcoholic extract on serum testosterone levels, sperm parameters, fertilization (IVF) success, and embryonic developmental potential to reach the blastocyst stage in a streptozotocin (STZ)-induced mouse model of diabetes. In this research, 30 male mice were distributed randomly into control, diabetic (streptozotocin 150 mg/kg) and diabetic + (400 mg/kg) groups. The results revealed a decrease in body and testis weight and elevated blood fasting blood sugar (FBS) levels in the diabetic group, compared with the control. However, treatment significantly increased body and testis weight, while serum FBS levels were decreased compared with the diabetic group. In addition, significantly increased blood testosterone levels compared with the diabetic group. Moreover, sperm parameters were improved considerably by treatment compared with the diabetic group. Furthermore, administration significantly promoted IVF success rate and development of fertilized oocytes compared with the diabetic group. In summary, our data indicated that enhanced sperm parameters, IVF success, and embryonic developmental competency in diabetic mice, probably because of its antioxidant effects. Therefore, could ameliorate sperm parameters that, in turn, increase fertilization outcomes in experimental-induced diabetes.
ISSN:0967-1994
1469-8730
DOI:10.1017/S0967199423000266