Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial

• Published in: Journal of periodontology (1970) 2024-02, Vol.95 (2), p.101-113
• Main Authors: Laky, Brenda, Bruckmann, Corinna, Blumenschein, Julian, Durstberger, Gerlinde, Haririan, Hady
• Format: Article
• Language: English
• Subjects: ascorbic acid; dietary supplements; periodontitis; selenium; vitamin E; zinc
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1002/JPER.23-0115

Background The aim of this double‐blind randomized placebo‐controlled clinical trial was to evaluate the efficacy of a multinutrient supplement as an add‐on therapy to scaling and root planing for patients with periodontitis. Methods Forty‐two patients with stage III or IV periodontitis were randomly allocated to a 2‐month treatment of either a multinutrient supplement containing vitamin C, vitamin E, zinc, selenium, alpha‐lipoic‐acid, cranberry extract, grapeseed extract, and coenzyme Q10 or placebo capsules as an adjunct to conservative periodontal therapy. Periodontal parameters, including probing pocket depth, gingival recession, bleeding on probing, approximal plaque index, and papillary bleeding index, were assessed. Clinical attachment loss, periodontal inflamed surface area, periodontal epithelial surface area, and percentages of pocket sites with ≤3, ≤4, ≥5, ≥6, ≥7, and ≥4 mm with bleeding on probing were calculated. Results All clinical parameters significantly improved from baseline to reevaluation within each group (p  0.05). Conclusions Multinutrient supplementation as an adjunct to nonsurgical treatment of periodontitis showed some additional benefit regarding probing‐pocket‐depth and bleeding‐on‐probing. However, the clinical relevance needs to be further explored.