Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy

Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of diseases including cancer. Tanshinone IIA (Tan IIA), a bioactive molecule found in the roots of the Traditional Chinese Medicine (TCM) herb Salvia milti...

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Bibliographic Details
Published in:Pharmacological reports 2023-08, Vol.75 (4), p.907-922
Main Authors: Alam, Syed Sahajada Mahafujul, Samanta, Arijit, Uddin, Faizan, Ali, Safdar, Hoque, Mehboob
Format: Article
Language:English
Subjects:
Drug Safety and Pharmacovigilance
Medicine
Pharmacotherapy
Pharmacy
Review
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Summary:Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of diseases including cancer. Tanshinone IIA (Tan IIA), a bioactive molecule found in the roots of the Traditional Chinese Medicine (TCM) herb Salvia miltiorrhiza , has been shown to have remarkable anticancer properties through several mechanisms, such as inhibition of tumor cell growth and proliferation, metastasis, invasion, and angiogenesis, as well as induction of apoptosis and autophagy. It has demonstrated excellent anticancer efficacy against cell lines from breast, cervical, colorectal, gastric, lung, and prostate cancer by modulating multiple signaling pathways including PI3K/Akt, JAK/STAT, IGF-1R, and Bcl-2–Caspase pathways. This review focuses on the role of Tan IIA in the treatment of various cancers, as well as the underlying molecular mechanisms.
ISSN:1734-1140
2299-5684
DOI:10.1007/s43440-023-00507-y