P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants

Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the...

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Published in:Chemistry & biodiversity 2023-08, Vol.20 (8), p.e202300427-n/a
Main Authors: Ortiz, Sergio, Šavikin, Katarina, Massicot, France, Olivier, Elodie, Dutot, Melody, Rat, Patrice, Deguin, Brigitte, Gođevac, Dejan, Menković, Nebojša, Živković, Jelena, Zdunić, Gordana, Boutefnouchet, Sabrina
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Bioassays
cinnamoyl-iridoids
dereplication
folk medicine
Herbal medicine
Inflammatory diseases
Medicinal plants
Metabolomics
P2X7 receptor
Plant extracts
Receptors
Scrophularia
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Summary:Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti‐inflammatory in European folk medicine by the YO‐PRO‐1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl‐iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti‐inflammatory mechanism of cinnamoyl‐iridoids bearing plants, which may involve the P2X7 receptor.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300427