Behavioral and neural correlates of pareidolic illusions in dementia with Lewy bodies

• Published in: Parkinsonism & related disorders 2023-08, Vol.113, p.105513-105513, Article 105513
• Main Authors: Watanabe, Hiroyuki, Uchiyama, Makoto, Yokoi, Kayoko, Mamiya, Yasuyuki, Narita, Wataru, Iizuka, Osamu, Baba, Toru, Suzuki, Kyoko, Mori, Etsuro, Nishio, Yoshiyuki
• Format: Article
• Language: English
• Subjects: Brain; Cognition; Hallucinations - diagnostic imaging; Hallucinations - etiology; Humans; Illusions - physiology; IMP-SPECT; Lewy body disease; Lewy Body Disease - complications; Lewy Body Disease - diagnostic imaging; Pareidolia; Visual hallucinations; Visual processing
• ISSN: 1353-8020; 1873-5126
• DOI: 10.1016/j.parkreldis.2023.105513

Pareidolia, a form of visual illusions phenomenologically similar to complex visual hallucinations, is a phenomenon that is associated with visual hallucinations in dementia with Lewy bodies (DLB). This study aimed to identify commonalities and differences in behavioral and neural correlates between pareidolic illusions and visual hallucinations in DLB. Forty-three patients with DLB underwent the scene pareidolia test, which evokes and measures pareidolic illusions, and standardized neuropsychological and behavioral assessments. Regional cerebral blood flow (rCBF) was measured by single-photon emission computed tomography. Factor analysis was performed to assess the relationships among pareidolic illusions, cognitive functions, and behavioral symptoms. Partial least squares correlation analysis was used to investigate the relationship between these symptoms and rCBF. Factor analysis yielded three behavior factors: the first factor (hallucinations/fluctuations) consisted of pareidolic illusions, visual hallucinations, and fluctuating cognition; the second factor (general cognitive function) consisted of general cognitive function and working memory; and the third factor (visual processing) consisted of visual processing and pareidolic illusions. Partial least squares correlation analysis identified two brain-behavior correlation patterns: (1) rCBF reduction in the frontal and perisylvian/periventricular regions was associated with lower general cognitive function and lower visual processing; and (2) rCBF reduction in the bilateral occipitotemporal cortex was associated with more severe hallucinations/fluctuations and lower visual processing. At the behavioral level, pareidolic illusions are associated with visual hallucinations, fluctuating cognition, and visual processing in DLB. At the neural level, pareidolic illusions may arise from the synergistic effects of global neuropathological changes and occipitotemporal cortical dysfunctions. •Pareidolic illusions (PI) were experimentally elicited in 43 DLB patients.•PI correlated with visual hallucinations, fluctuation and visual dysfunction.•PI correlated with global and occipitotemporal rCBF reduction.