Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks

Currently, obesity has achieved epidemic levels in reproductive-aged women with a myriad of consequences. Obesity is susceptible to several reproductive complications that eventually affect fertility rates. These complications originate from the deteriorated quality of oocytes from mothers with obes...

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Bibliographic Details
Published in:Obesity reviews 2023-10, Vol.24 (10), p.e13603-e13603
Main Authors: Muhammad, Tahir, Wan, Yanling, Lv, Yue, Li, Hanzhen, Naushad, Wasifa, Chan, Wai-Yee, Lu, Gang, Chen, Zi-Jiang, Liu, Hongbin
Format: Article
Language:English
Subjects:
Aneuploidy
Females
Fertility
Gametocytes
Implantation
Obesity
Oocytes
Oxidative stress
Pregnancy
Pregnancy complications
Reactive oxygen species
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Summary:Currently, obesity has achieved epidemic levels in reproductive-aged women with a myriad of consequences. Obesity is susceptible to several reproductive complications that eventually affect fertility rates. These complications originate from the deteriorated quality of oocytes from mothers with obesity, which increases the probability of chromosomal aneuploidy, elevated reactive oxygen species production, compromised embryonic developmental competency, and eventually reduced fertility. Maternal obesity is linked to pregnancy complications such as implantation error, abortion, miscarriage, and early pregnancy loss. This review highlights the adverse effects of maternal obesity on female fertility, with a focus on the mechanistic link between maternal obesity and oocyte quality and discusses possible measures to reduce its associated risks.
ISSN:1467-7881
1467-789X
DOI:10.1111/obr.13603