Associations between the gut microbiome and metabolic, inflammatory, and appetitive effects of sleeve gastrectomy

Summary The complex and multifactorial etiology of obesity creates challenges for its effective long‐term management. Increasingly, the gut microbiome is reported to play a key role in the maintenance of host health and wellbeing, with its dysregulation associated with chronic diseases such as obesi...

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Bibliographic Details
Published in:Obesity reviews 2023-09, Vol.24 (9), p.e13600-n/a
Main Authors: Brown, Holly N., Barber, Thomas, Renshaw, Derek, Farnaud, Sebastien, Oduro‐Donkor, Dominic, Turner, Mark C.
Format: Article
Language:English
Subjects:
Chronic illnesses
Digestive system
Energy harvesting
Energy storage
Gastrectomy
Gastrointestinal surgery
Gastrointestinal tract
gut microbiome
Inflammation
Intestinal microflora
Maintenance
Metabolism
Metabolites
Microbiomes
Microbiota
Obesity
Pathogenesis
Satiety
sleeve gastrectomy
Sleeves
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Summary:Summary The complex and multifactorial etiology of obesity creates challenges for its effective long‐term management. Increasingly, the gut microbiome is reported to play a key role in the maintenance of host health and wellbeing, with its dysregulation associated with chronic diseases such as obesity. The gut microbiome is hypothesized to contribute to obesity development and pathogenesis via several pathways involving food digestion, energy harvest and storage, production of metabolites influencing satiety, maintenance of gut barrier integrity, and bile acid metabolism. Moreover, the gut microbiome likely contributes to the metabolic, inflammatory, and satiety benefits and sustained weight‐loss effects following bariatric procedures such as sleeve gastrectomy. While the field of gut microbiome research in relation to obesity and sleeve gastrectomy outcomes is largely in its infancy, the gut microbiome nonetheless holds great potential for understanding some of the mechanisms behind sleeve gastrectomy outcomes as well as for optimizing post‐surgery benefits. This review will explore the current literature within the field as well as discuss the current limitations, including the small sample size, variability in methodological approaches, and lack of associative data, which need to be addressed in future studies.
ISSN:1467-7881
1467-789X
DOI:10.1111/obr.13600