The Structure of Maneb, An Important Manganese‐Containing Bis(dithiocarbamate) Fungicide

Maneb is a manganese(II)‐containing fungicide with a multi‐site effect and no resistance, therefore it is widely applied in many parts of the world. There is, however, mounting evidence for neurotoxic effects with Parkinson‐like symptoms (manganism) related to usage of Maneb. Due to its insolubility...

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Bibliographic Details
Published in:Chemistry : a European journal 2023-10, Vol.29 (55), p.e202301721-n/a
Main Authors: Kubens, Laura, Truong, Khai‐Nghi, Lehmann, Christian W., Lützenkirchen‐Hecht, Dirk, Bornhorst, Julia, Mohr, Fabian
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Chemistry
dithiocarbamate
Electron diffraction
Fungicides
Maneb
Manganese
Molecular structure
Neurotoxicity
Paramagnetism
X-ray diffraction
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Summary:Maneb is a manganese(II)‐containing fungicide with a multi‐site effect and no resistance, therefore it is widely applied in many parts of the world. There is, however, mounting evidence for neurotoxic effects with Parkinson‐like symptoms (manganism) related to usage of Maneb. Due to its insolubility in most solvents and its paramagnetism, structural elucidation is not trivial, and thus its exact molecular structure remains unknown. We report herein a synthesis procedure to prepare Maneb reproducibly in pure form and the use of various analytical techniques including X‐ray diffraction, X‐ray absorption spectroscopy and electron diffraction to determine the molecular structure of Maneb in the solid state and also in solution. Molecular structure of Maneb determined: Over 70 years after patent publication, the mystery of the structure of the surprisingly stable manganese(II)‐containing ethylene bis(dithiocarbamate) fungicide, which is extensively used in agriculture, has finally been solved.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202301721