Experimental glaucoma triggers a pro-oxidative and pro-inflammatory state in the rat cornea

Increasing evidence suggests that glaucoma affects the ocular surface. We aimed to investigate the cellular mechanisms underlying the glaucoma-associated corneal alterations in an animal model. Wistar rats underwent the cauterization of two episcleral veins of the left eye to elevate the intraocular...

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Bibliographic Details
Published in:Biochimica et biophysica acta. General subjects 2023-09, Vol.1867 (9), p.130426-130426, Article 130426
Main Authors: Hvozda Arana, Ailen G., Lerner, S. Fabián, Reides, Claudia G., Contin, Mario, Tripodi, Valeria, Lasagni Vitar, Romina M., Ferreira, Sandra M.
Format: Article
Language:English
Subjects:
Antioxidants
Cornea
Glaucoma
Inflammation
Oxidative stress
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Summary:Increasing evidence suggests that glaucoma affects the ocular surface. We aimed to investigate the cellular mechanisms underlying the glaucoma-associated corneal alterations in an animal model. Wistar rats underwent the cauterization of two episcleral veins of the left eye to elevate the intraocular pressure (ipsilateral, G-IL). Control animals received a sham procedure (C-IL). Contralateral eyes did not receive any procedure (G-CL or C-CL). Enzymes related to the redox status, oxidative damage to macromolecules, and inflammatory markers were assessed in corneal lysates. Compared to C-IL, NOX4, NOX2, and iNOS expression was increased in G-IL (68%, p 
ISSN:0304-4165
1872-8006
DOI:10.1016/j.bbagen.2023.130426