Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio and Cardiorenal Syndrome Type 2 in the Systemic Sclerosis EUSTAR Cohort

OBJECTIVEThe aim of the study was to evaluate the association between the tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP) ratio and estimated glomerular filtration rate (eGFR) and their association with mortality in the European Scleroderma Trials and Res...

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Published in:Arthritis care & research (2010) 2023-09
Main Authors: Colalillo, Amalia, Pellicano, Chiara, Ananyeva, Lidia P., Hachulla, Eric, Cuomo, Giovanna, Györfi, Andrea‐Hermina, Czirják, László, de Vries‐Bouwstra, Jeska, Mouthon, Luc, Poormoghim, Hadi, Del Galdo, Francesco, Hunzelmann, Nicolas, Spierings, Julia, Kuwana, Masataka, Rosato, Edoardo
Format: Article
Language:English
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Summary:OBJECTIVEThe aim of the study was to evaluate the association between the tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP) ratio and estimated glomerular filtration rate (eGFR) and their association with mortality in the European Scleroderma Trials and Research (EUSTAR) cohort. METHODSPatients with systemic sclerosis (SSc) from the EUSTAR database with TAPSE, sPAP, and parameters required to calculate eGFR were included. Logistic regression and Cox regression analysis were performed to evaluate TAPSE/sPAP as a risk factor for chronic kidney disease (CKD) and overall survival. RESULTSA total of 2,370 patients with SSc were included; 284 (12%) patients had CKD stage 3a-5. TAPSE/sPAP (odds ratio [OR] 0.479; 95% CI 0.310-0.743; P
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.25196