Conjugated carbon monoxide-releasing molecules have broad-spectrum antimicrobial activity

To test the antimicrobial effect of carbon monoxide-releasing molecules (CORMs) conjugated with azoles on different microorganisms. We used broth microdilution, checkerboard and cytotoxicity assays, as well as imaging, fluorescence and bioluminescence experiments to study [Re(CO) (2,2′-bipyridyl)(Ct...

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Published in:Future medicinal chemistry 2023-06, Vol.15 (12), p.1037-1048
Main Authors: S Mendes, Sofia, Sorg, Moritz, Luís, Cláudia Malta, Fontinha, Diana, Francisco, Denise, Moita, Diana, C Romão, Carlos, G Pinho, Mariana, Pimentel, Catarina, Prudêncio, Miguel, M Saraiva, Lígia
Format: Article
Language:English
Subjects:
antimicrobials
carbon monoxide-releasing molecules
spp
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Summary:To test the antimicrobial effect of carbon monoxide-releasing molecules (CORMs) conjugated with azoles on different microorganisms. We used broth microdilution, checkerboard and cytotoxicity assays, as well as imaging, fluorescence and bioluminescence experiments to study [Re(CO) (2,2′-bipyridyl)(Ctz)] (also known as ReBpyCtz). ReBpyCtz exhibits a low minimum inhibitory concentration value, increases the intracellular formation of reactive oxygen species and causes significant alterations on ‘s membrane. ReBpyCtz is active against fungi, having a more prolonged fungicidal effect on than clotrimazole and is selectively active on blood-stage malaria parasites, at a concentration that is not toxic to kidney epithelial cells. Conjugated CORMs have the potential to be active against different types of pathogens, thus constituting a promising class of broad-spectrum antimicrobials.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2023-0103