Efficacy of Bioactive Compounds in the Regulation of Metabolism and Pathophysiology in Cardiovascular Diseases

Purpose of Review An imbalance in reactive oxygen species (ROS) homeostasis can wreak damage to metabolic and physiological processes which can eventually lead to an advancement in cardiovascular diseases (CVD). Mitochondrial dysfunction is considered as a key source of ROS. The purpose of the curre...

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Bibliographic Details
Published in:Current cardiology reports 2023-09, Vol.25 (9), p.1041-1052
Main Authors: Pawar, Vishakha Anand, Srivastava, Shivani, Tyagi, Anuradha, Tayal, Rajul, Shukla, Surendra Kumar, Kumar, Vinay
Format: Article
Language:English
Subjects:
Cardiology
Medicine
Medicine & Public Health
New Therapies for Cardiovascular Disease (AA Bavry and M Massoomi
Section Editors
Topical Collection on New Therapies for Cardiovascular Disease
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Summary:Purpose of Review An imbalance in reactive oxygen species (ROS) homeostasis can wreak damage to metabolic and physiological processes which can eventually lead to an advancement in cardiovascular diseases (CVD). Mitochondrial dysfunction is considered as a key source of ROS. The purpose of the current review is to concisely discuss the role of bioactive compounds in the modulation of cardiovascular metabolism and their potential application in the management of cardiovascular diseases. Recent Findings Recently, it has been shown that bioactive compounds exhibit immunomodulatory function by regulating inflammatory pathways and ROS homeostasis. It has also been reported that bioactive compounds regulate mitochondria dynamics, thus modulating the autophagy and energy metabolism in the cells. Summary In the present article, we have discussed the roles of different bioactive compounds in the modulation of different inflammatory drivers. The functional properties of bioactive compounds in mitochondrial dynamics and its impact on cardiac disease protection have been briefly summarized. Furthermore, we have also discussed various aspects of bioactive compounds with respect to metabolism, immune modulation, circadian rhythm, and its impact on CVD’s pathophysiology.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-023-01917-3