Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes

Arginases are bimanganese enzymes involved in many human illnesses, and thus are targets for disease treatments. The screening of traditional medicinal plants demonstrated that an ethanol extract of Curcuma comosa rhizomes showed significant human arginase I and II inhibitory activity, and further f...

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Bibliographic Details
Published in:Journal of natural medicines 2023-09, Vol.77 (4), p.891-897
Main Authors: Hoang, Nhat Nam, Kodama, Takeshi, Nakashima, Yu, Do, Kiep Minh, Hnin, Saw Yu Yu, Lee, Yuan-E, Prema, Ikumi, Naotaka, Morita, Hiroyuki
Format: Article
Language:English
Subjects:
Arginase
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Curcuma
Curcuma comosa
Humans
Medicinal Chemistry
Medicinal plants
Molecular Structure
Original Paper
Pharmacology/Toxicology
Pharmacy
Plant Sciences
Rhizome
Rhizomes
Sesquiterpenes - pharmacology
Sesquiterpenoids
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Summary:Arginases are bimanganese enzymes involved in many human illnesses, and thus are targets for disease treatments. The screening of traditional medicinal plants demonstrated that an ethanol extract of Curcuma comosa rhizomes showed significant human arginase I and II inhibitory activity, and further fractionation led to the isolation of three known guaiane sesquiterpenoids, alismoxide ( 1 ), 7α,10α-epoxyguaiane-4α,11-diol ( 2 ) and guaidiol ( 3 ). Tests of their inhibitory activities on human arginases I and II revealed that 1 exhibited selective and potent competitive inhibition for human arginase I (IC 50  = 30.2 μM), whereas the other compounds lacked inhibitory activities against human arginases. To the best of our knowledge, this is the first demonstration of human arginase I inhibitory activity by a sesquiterpenoid. Thus, 1 is a primary and specific inhibitory molecule against human arginase I.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-023-01731-9