Cobalt(III)-Catalyzed Directed C‑7 Selective C–H Alkynylation of Indolines with Bromoalkynes

A cobalt­(III)-catalyzed directed C-7 alkynylation of indolines with easily accessible bromoalkynes has been developed. The reaction has a broad substrate scope with excellent yields and represents a powerful route to the synthesis of 7-alkynyl-substituted indolines. In addition, the reaction can be...

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Bibliographic Details
Published in:Organic letters 2023-07, Vol.25 (29), p.5411-5415
Main Authors: Niu, Rui-Han, Zhang, Jing, Zhao, Ru-Yuan, Luo, Quan-Jian, Li, Jin-Heng, Sun, Bo
Format: Article
Language:English
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Summary:A cobalt­(III)-catalyzed directed C-7 alkynylation of indolines with easily accessible bromoalkynes has been developed. The reaction has a broad substrate scope with excellent yields and represents a powerful route to the synthesis of 7-alkynyl-substituted indolines. In addition, the reaction can be extended to the coupling of N-aryl 7-azaindoles, highlighting the synthetic practicability of the strategy.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c01584