Characteristics of pathologic complete response for locally advanced rectal cancer

Neoadjuvant chemoradiation (NACRT) is the standard of care for locally advanced rectal cancers. The purpose of this study was to determine patient and tumor factors associated with a pathologic complete response (pCR). The National Surgical Quality Improvement Program proctectomy-targeted database w...

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Bibliographic Details
Published in:The American journal of surgery 2023-12, Vol.226 (6), p.873-877
Main Authors: Cloos, Adam J., Schissel, Makayla, Batra, Rishi, Donahue, Steven R., Wenos, Chelsea D., Kumar, Terrence, Leinicke, Jennifer A., Thompson, Jon S., Langenfeld, Sean J.
Format: Article
Language:English
Subjects:
Associative factors
Body mass index
Cancer
Cancer therapies
Chemoradiotherapy
Colorectal cancer
Demographics
Diabetes
Ethnicity
Gender
Hypertension
Pathologic complete response
Patients
Quality control
Rectal cancer
Rectum
Regression analysis
Tumors
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Summary:Neoadjuvant chemoradiation (NACRT) is the standard of care for locally advanced rectal cancers. The purpose of this study was to determine patient and tumor factors associated with a pathologic complete response (pCR). The National Surgical Quality Improvement Program proctectomy-targeted database was utilized to identify all patients from 2016 to 2020 who underwent NACRT followed by proctectomy with curative intent for T3-4N0-2 rectal cancers. A total of 1891 patients were included, of which 253 (13.4%) demonstrated a pCR. Pretreatment N0 staging was associated with a higher rate of pCR (18.9%) when compared to N1 (6.7%) and N2 (6.7%) (p 
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2023.07.023