Metastatic Neuroendocrine Neoplasms to the Pancreas: Two Unusual Cases and a Review of the Literature

Neuroendocrine tumor metastases to the pancreas are rare, and they share substantial overlap with the significantly more common primary pancreatic neuroendocrine neoplasms, representing a potential diagnostic pitfall. Elucidating whether a neuroendocrine tumor within the pancreas is a primary neopla...

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Bibliographic Details
Published in:International journal of surgical pathology 2024-05, Vol.32 (3), p.523-532
Main Authors: DelBaugh, Regina M., Kerr, Darcy A., Dominguez-Konicki, Lillian, Beard, Jonathan A., Gordon, Stuart R., Adler, Jeffrey M., Liu, Xiaoying
Format: Article
Language:English
Subjects:
Carcinoid Tumor - pathology
Carcinoma, Neuroendocrine - diagnosis
Humans
Lung Neoplasms - pathology
Neuroendocrine Tumors - pathology
Pancreas - pathology
Pancreatic Neoplasms - diagnosis
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Summary:Neuroendocrine tumor metastases to the pancreas are rare, and they share substantial overlap with the significantly more common primary pancreatic neuroendocrine neoplasms, representing a potential diagnostic pitfall. Elucidating whether a neuroendocrine tumor within the pancreas is a primary neoplasm versus a metastasis has significant prognostic and treatment implications. Correlation with clinical history and imaging as well as incorporating an appropriate immunohistochemical panel are essential to establish the correct diagnosis. Herein, we present 2 rare neuroendocrine tumors that metastasized to the pancreas: a medullary thyroid carcinoma and an atypical carcinoid tumor of lung origin. We also provide a brief review of the literature.
ISSN:1066-8969
1940-2465
DOI:10.1177/10668969231185067