Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists: Endorsed by the Mycoses Study Group Education and Research Consortium

Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections. Most triazole antifungals require therapeutic drug monitoring (TDM) due to highly variable pharmacokinetics, kn...

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Bibliographic Details
Published in:Pharmacotherapy 2023-10, Vol.43 (10), p.1043-1050
Main Authors: McCreary, Erin K, Davis, Matthew R, Narayanan, Navaneeth, Andes, David R, Cattaneo, Dario, Christian, Robbie, Lewis, Russell E, Watt, Kevin M, Wiederhold, Nathan P, Johnson, Melissa D
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacokinetics
Antifungal Agents - therapeutic use
Communicable Diseases - drug therapy
Drug interaction
Drug Monitoring
Fluconazole
Humans
Infectious diseases
Itraconazole
Mycoses - drug therapy
Pharmacists
Pharmacodynamics
Pharmacokinetics
Posaconazole
Triazoles
Triazoles - therapeutic use
Voriconazole
Voriconazole - therapeutic use
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Summary:Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections. Most triazole antifungals require therapeutic drug monitoring (TDM) due to highly variable pharmacokinetics, known drug interactions, and established relationships between exposure and response. On behalf of the Society of Infectious Diseases Pharmacists (SIDP), this insight describes the pharmacokinetic principles and pharmacodynamic targets of commonly used triazole antifungals and provides the rationale for utility of TDM within each agent.
ISSN:0277-0008
1875-9114
DOI:10.1002/phar.2850