The effect of intraperitoneal administration of dexamethasone on postoperative analgesia after laparoscopic cholecystectomy: a prospective randomized controlled double-blind study

• Published in: The Pan African medical journal 2023, Vol.45, p.14-14
• Main Authors: Abdelhedi, Ahmed, Ketata, Salma, Kardoun, Nizar, Keskes, Mariem, Zouche, Imen, Ayedi, Amal, Doukeli, Oussema, Khrouf, Mariem, Fendri, Sami, Zouari, Amine, Cheikhrouhou, Hichem
• Format: Article
• Language: fre
• Subjects: Abdominal Pain - etiology; Analgesia - adverse effects; Analgesia - methods; Analgesics, Opioid; Cholecystectomy, Laparoscopic - adverse effects; Cholecystectomy, Laparoscopic - methods; Dexamethasone; Double-Blind Method; Humans; Nausea - etiology; Pain, Postoperative - drug therapy; Pain, Postoperative - etiology; Pain, Postoperative - prevention & control; Prospective Studies; Shoulder Pain - etiology; Shoulder Pain - prevention & control; Vomiting - etiology
• ISSN: 1937-8688
• DOI: 10.11604/pamj.2023.45.14.36438

the effect of intravenous corticosteroids on postoperative pain has been well demonstrated; however, few studies have focused on the efficacy of intraperitoneal corticosteroid use after laparoscopic surgery. The purpose of this study was to evaluate the effect of intraperitoneal administration of dexamethasone on postoperative analgesia after laparoscopic cholecystectomy. we conducted a prospective, randomised, double-blind, controlled study, including patients scheduled for laparoscopic cholecystectomy and randomised into two groups: the group D (receiving 16 ml: 12 ml saline and 4 ml solution containing 16mg dexamethasone) and the group T (receiving 16 ml saline). The primary endpoint was: Visual Analogue Scale (VAS) for abdominal pain during the first 24 hours after surgery. The secondary endpoints were the incidence of shoulder pain, time to first request for analgesia, the consumption of morphine in the post-intervention surveillance room (PACU), the consumption of non-opioid analgesics and the incidence of nausea and vomiting during the first 24 hours after surgery as well as the presence of complications. sixty patients were included in the study and divided into two groups of 30. Demographic parameters, duration of surgical and anesthesia procedures, as well as intraoperative fentanyl consumption were comparable between the two groups. Abdominal pain VAS values (p≤0.001), the incidence of shoulder pain (p