The effect of renal replacement therapy on health-related quality of life in end-stage renal disease: a meta-analysis

Background End-stage renal disease (ESRD) patients judge health-related quality of life (HRQoL) as an essential outcome . In meta-analysis studies, there is ongoing debate regarding the impact of renal replacement therapy (RRT) methods on HRQoL in ESRD patients. Hence, the main objective of this stu...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2023-10, Vol.27 (10), p.829-846
Main Authors: Fidan, Cuma, Ağırbaş, İsmail
Format: Article
Language:English
Subjects:
End-stage renal disease
Hemodialysis
Kidney diseases
Kidney transplantation
Medicine
Medicine & Public Health
Meta-analysis
Nephrology
Original Article
Patients
Peritoneal dialysis
Quality of life
Renal replacement therapy
Sensitivity analysis
Statistical analysis
Urology
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Summary:Background End-stage renal disease (ESRD) patients judge health-related quality of life (HRQoL) as an essential outcome . In meta-analysis studies, there is ongoing debate regarding the impact of renal replacement therapy (RRT) methods on HRQoL in ESRD patients. Hence, the main objective of this study was to examine the influence of RRT method utilization on HRQoL in individuals with ESRD. Additionally, the secondary objective was to explore the impact of RRT method use on HRQoL, considering various moderator variables. Methods RRT methods called hemodialysis (HD), peritoneal dialysis (PD), home dialysis (HoD), and kidney transplantation (KT) are used to treat ESRD. HD was defined as in-center HD (ICHD) and home HD (HHD). HoD was defined as HHD and PD. The estimated Hedges’ g were conducted by random effect meta-analysis. Results A total of 111 publications, including 50.151 patients, were included. KT was better at improving patients’ HRQoL than other methods. PD was better at improving patients’ HRQoL than HD. HoD was better at improving patients’ HRQoL than ICHD. Sensitivity analyses yielded similar results. Publication bias was not tested. The subgroup and meta-regression analyses showed that the moderating variables had a statistically significant effect on the HRQoL of patients with ESRD. Conclusion For the treatment of ESRD, either KT, PD, or HoD can be used in terms of HRQoL. We need to improve the factors affecting the HRQoL of ESRD patients undergoing HD and ICHD. Healthcare professionals should consider the factors that influence HRQoL and choose an RTT method for each ESRD patient.
ISSN:1342-1751
1437-7799
1437-7799
DOI:10.1007/s10157-023-02377-3