Development and validation of a nomogram for predicting the risk of vasovagal reactions after plasma donation

Vasovagal reactions (VVRs) are the most common adverse reactions and are frequently associated with serious donor adverse events. Even mild VVRs can lead to a significant reduction in the likelihood of subsequent donations. The purpose of this study is to explore the factors related to the occurrenc...

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Bibliographic Details
Published in:Journal of clinical apheresis 2023-10, Vol.38 (5), p.622-631
Main Authors: Zhao, Peizhe, Dong, Demei, Dong, Rong, Zhou, Yuan, Hong, Yan, Xiao, Guanglin, Li, Zhiye, Su, Xuelin, Zheng, Xingyou, Liu, Xia, Zhang, Demei, Li, Ling, Liu, Zhong
Format: Article
Language:English
Subjects:
Nomograms
Plasma
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Summary:Vasovagal reactions (VVRs) are the most common adverse reactions and are frequently associated with serious donor adverse events. Even mild VVRs can lead to a significant reduction in the likelihood of subsequent donations. The purpose of this study is to explore the factors related to the occurrence of VVRs after plasma donation and to construct a nomogram to identify individuals at risk for VVRs to improve the safety of plasma donors. We collected the donation data from July 2019 to June 2020 from a plasma center in Sichuan, China, to explore the independent risk factors for vasovagal reactions. From these data, we constructed and validated a predictive model for vasovagal reactions. VVRs after plasma donation occurred 737 times in 120 448 plasma donations (0.66%). Gender, season, donor status, weight, pulse, duration of donation, and cycle were independent risk factors for VVRs (P
ISSN:0733-2459
1098-1101
DOI:10.1002/jca.22074