Fibrotic Burden in Patients With Hepatitis B Virus–Related Cirrhosis Is Independently Associated With Poorer Kidney Outcomes

Abstract Background We investigated whether higher fibrotic burden was independently associated with poorer kidney outcomes in patients with hepatitis B virus (HBV)–related cirrhosis. Methods A total of 1691 patients with radiologically diagnosed HBV-related cirrhosis but without baseline chronic ki...

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Bibliographic Details
Published in:The Journal of infectious diseases 2024-01, Vol.229 (1), p.108-116
Main Authors: Jung, Chan-Young, Jung, Hui-Yun, Kim, Hyung Woo, Ryu, Geun Woo, Lee, Jung Il, Ahn, Sang Hoon, Kim, Seung Up, Kim, Beom Seok
Format: Article
Language:English
Subjects:
Elasticity Imaging Techniques - adverse effects
Female
Hepatitis B virus
Hepatitis B, Chronic - complications
Humans
Kidney
Liver Cirrhosis - etiology
Male
Middle Aged
Renal Insufficiency, Chronic - complications
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Summary:Abstract Background We investigated whether higher fibrotic burden was independently associated with poorer kidney outcomes in patients with hepatitis B virus (HBV)–related cirrhosis. Methods A total of 1691 patients with radiologically diagnosed HBV-related cirrhosis but without baseline chronic kidney disease (CKD) who underwent transient elastography (TE) between March 2012 and August 2018 were selected. The study outcome was the composite of development of incident CKD, defined as the occurrence of estimated glomerular filtration rate (eGFR)
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiad273