Comparative study of two different rat models of stress urinary incontinence

Introduction and hypothesis The purpose of this study was to compare the success rate and urodynamic characteristics of the rat model of stress Urinary incontinence established by ovariectomy at different times after vaginal dilation. Methods Eighty female rats were randomly divided into three group...

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Bibliographic Details
Published in:International Urogynecology Journal 2023-12, Vol.34 (12), p.2867-2872
Main Authors: Qu, Zhiyu, Chen, Bingli, Yang, Mengyi, Chen, Yuelai, Ming, Shuren, Hou, Wenguang
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Female
Gynecology
Medicine
Medicine & Public Health
Oophorectomy
Original Article
Rats
Rats, Sprague-Dawley
Urethra
Urinary incontinence
Urinary Incontinence, Stress - etiology
Urodynamics
Urology
Vagina
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Summary:Introduction and hypothesis The purpose of this study was to compare the success rate and urodynamic characteristics of the rat model of stress Urinary incontinence established by ovariectomy at different times after vaginal dilation. Methods Eighty female rats were randomly divided into three groups: the control group ( n  = 20), model group A ( n  = 30), i.e., the animals received colpectasis and bilateral oophorectomy within 1 day; model group B ( n  = 30), i.e., the animals received bilateral oophorectomy 1 week after colpectasis. The sneeze test and urodynamics were tested. Results There was no significant difference between the model group A and the model group B ( p  > 0.05) in the sneeze test. The leak point pressure (LPP) of model groups A and B was lower than that of the control group ( p  
ISSN:0937-3462
1433-3023
DOI:10.1007/s00192-023-05593-3