Pulmonary Tuberculosis in Severely Malnourished Children Admitted to Nutrition Rehabilitation Centers: A Multicenter Study

Objectives To identify prevalence of pulmonary tuberculosis (TB) in severely malnourished children admitted to nutritional rehabilitation centers. Methods A multicenter cross-sectional study involving 41 nutrition rehabilitation centres (NRCs) across India was carried out to document prevalence of p...

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Published in:Indian journal of pediatrics 2024-08, Vol.91 (8), p.773-780
Main Authors: Singh, Manjula, Dhingra, Bhavna, Bishnu, Bipra, Pandey, Dhruvendra, Anand, Praveen K., Gupta, Sarika, Das, Vidyanand Ravi, Dhochak, Nitin, Kabra, S. K.
Format: Article
Language:English
Subjects:
Child
Child Nutrition Disorders - complications
Child Nutrition Disorders - epidemiology
Child, Preschool
Cross-Sectional Studies
Female
Gynecology
Humans
India - epidemiology
Infant
Male
Medicine
Medicine & Public Health
Original Article
Pediatrics
Prevalence
Rehabilitation Centers
Tuberculin Test
Tuberculosis, Pulmonary - complications
Tuberculosis, Pulmonary - epidemiology
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Summary:Objectives To identify prevalence of pulmonary tuberculosis (TB) in severely malnourished children admitted to nutritional rehabilitation centers. Methods A multicenter cross-sectional study involving 41 nutrition rehabilitation centres (NRCs) across India was carried out to document prevalence of pulmonary tuberculosis in acute severe malnourished children admitted in NRCs. After training of the NRC staff to follow algorithm provided by national tuberculosis elimination program, children admitted to NRCs were screened for pulmonary tuberculosis. Results A total of 4356 children were enrolled across all the sites. Gastric aspirate for Cartridge based nucleic acid amplification test (CBNAAT), tuberculin skin test (TST) and X-ray film of chest were done in more than 99% of enrolled subjects. A total of 189 children (4.3%) had pulmonary tuberculosis. Eighty-seven (1.99%) were microbiologically confirmed by positive CBNAAT. On multivariate analysis, only significant association was with history of contact with TB patient in family. Conclusions The present results suggest that a significant proportion (>4%) of children admitted in NRCs suffer from pulmonary tuberculosis. It is feasible to improve diagnosis of tuberculosis as a whole and microbiologically confirmed TB.
ISSN:0019-5456
0973-7693
0973-7693
DOI:10.1007/s12098-023-04723-5