Influence of interleukin-8 polymorphism on endometriosis-related pelvic pain

Endometriosis presents a pro-inflammatory microenvironment influenced by cytokines, such as interleukin (IL)-8, which expression may be influenced by genetic polymorphisms. Therefore, we aimed to investigate the role of interleukin (IL)-8 rs4073 polymorphism in endometriosis’ development and its rel...

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Bibliographic Details
Published in:Human immunology 2023-10, Vol.84 (10), p.561-566
Main Authors: Cardoso, Jéssica Vilarinho, Machado, Daniel Escorsim, da Silva, Mayara Calixto, de Mello, Matheus Pereira, Berardo, Plinio Tostes, Medeiros, Rui, Perini, Jamila Alessandra
Format: Article
Language:English
Subjects:
Chronic pelvic pain
Endometriosis
Inflammation
Interleukin
Polymorphism
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Summary:Endometriosis presents a pro-inflammatory microenvironment influenced by cytokines, such as interleukin (IL)-8, which expression may be influenced by genetic polymorphisms. Therefore, we aimed to investigate the role of interleukin (IL)-8 rs4073 polymorphism in endometriosis’ development and its related symptoms. A case-control study was conducted with 207 women with endometriosis and 193 healthy controls. Polymorphism was genotyped using a TaqMan validated assay. Associations were evaluated by binary logistic regression, using odds ratios (OR) and 95 % confidence intervals (CI), and P ≤ 0.05 was considered significant. Cases were younger (36 ± 6.8 versus 39 ± 8.4) and had lower body mass index (26.5 ± 5.3 versus 35.7 ± 6.3 Kg/m2) than controls (P 
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2023.07.004