Serum 25(OH)D Concentration, Vitamin D Supplementation, and Risk of Cardiovascular Disease and Mortality in Patients with Type 2 Diabetes or Prediabetes: a Systematic Review and Dose–Response Meta-Analysis

Evidence is uncertain about the association between serum 25-hydroxyvitamin D (25(OH)D) concentration and health outcomes in people with type 2 diabetes. We aimed to assess the association between vitamin D status and all-cause mortality and cardiovascular disease in people with type 2 diabetes. We...

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Published in:The American journal of clinical nutrition 2023-09, Vol.118 (3), p.697-707
Main Authors: Jayedi, Ahmad, Daneshvar, Mojtaba, Jibril, Aliyu Tijani, Sluyter, John D., Waterhouse, Mary, Romero, Briony Duarte, Neale, Rachel E., Manson, JoAnn E., Shab-Bidar, Sakineh
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Calciferol
Cardiovascular disease
Cardiovascular diseases
Clinical trials
Cohort analysis
cohort studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Dietary supplements
Health risks
Meta-analysis
Morbidity
Mortality
randomized trials
Risk
Risk assessment
serum 25(OH)D
Systematic review
type 2 diabetes
Vitamin D
Vitamin deficiency
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Summary:Evidence is uncertain about the association between serum 25-hydroxyvitamin D (25(OH)D) concentration and health outcomes in people with type 2 diabetes. We aimed to assess the association between vitamin D status and all-cause mortality and cardiovascular disease in people with type 2 diabetes. We did a systematic search in PubMed, Scopus, CENTRAL, and Web of Science until May 2022. We selected 1) cohort studies investigating the association between serum 25(OH)D concentration and mortality or cardiovascular disease in people with type 2 diabetes or prediabetes and 2) randomized trials of vitamin D supplementation in these patients. We used random-effects pairwise meta-analyses to calculate summary relative risks (RRs) and 95% confidence intervals (CI). 21 cohort studies and 6 randomized trials were included. Compared with sufficient vitamin D status (≥50 nmol/L), the RR of all-cause mortality was 1.36 (95% CI: 1.23, 1.49; n = 11 studies, GRADE = moderate) for vitamin D insufficiency (25 to
ISSN:0002-9165
1938-3207
DOI:10.1016/j.ajcnut.2023.07.012