Health-related quality of life analyses in nonfunctioning pituitary macroadenoma patients identifies at-risk populations

Purpose The quality of life (QoL) impact of multidisciplinary treatment for patients with nonfunctioning pituitary macroadenomas (NFPMA) is unclear. We sought to investigate associations between patient factors, clinical data, and patient-reported QoL in patients with NFPMA. Methods Patients with tr...

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Bibliographic Details
Published in:Pituitary 2023-08, Vol.26 (4), p.510-520
Main Authors: Wisdom, Amy J., Dyer, M Aiven, Horick, Nora K., Yeap, Beow. Y., Miller, Karen K., Swearingen, Brooke, Loeffler, Jay S., Shih, Helen A.
Format: Article
Language:English
Subjects:
At risk populations
Cognitive ability
Endocrinology
Fatigue
Human Physiology
Hypopituitarism
Medicine
Medicine & Public Health
Patients
Pituitary
Quality of life
Radiation therapy
Surgery
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Summary:Purpose The quality of life (QoL) impact of multidisciplinary treatment for patients with nonfunctioning pituitary macroadenomas (NFPMA) is unclear. We sought to investigate associations between patient factors, clinical data, and patient-reported QoL in patients with NFPMA. Methods Patients with treated NFPMA and > 1 year of follow up after transsphenoidal surgery (TSS) and with no evidence of progressive disease were evaluated utilizing the following patient-reported outcome measures: RAND-36-Item Health Survey, Multidimensional Fatigue Inventory, Cognitive Failures Questionnaire. Results 229 eligible patients completed QoL questionnaires a median of 7.7 years after initial transsphenoidal surgery (TSS). 25% of participants received radiation therapy (RT) a median of 2.0 years (0.1–22.5) after initial TSS. Patients who received RT were younger (median age 46 v 58, p 
ISSN:1386-341X
1573-7403
DOI:10.1007/s11102-023-01334-3