Ru(phen)3 Cl2 -Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes

A novel Ru(phen)3 Cl2 -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The r...

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Bibliographic Details
Published in:ChemistryOpen (Weinheim) 2023-07, Vol.12 (7), p.e202300068
Main Authors: Su, Wenhao, Cui, Jing, Zeng, Runsheng
Format: Article
Language:English
Online Access:Get full text
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Summary:A novel Ru(phen)3 Cl2 -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.A novel Ru(phen)3 Cl2 -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.
ISSN:2191-1363
2191-1363
DOI:10.1002/open.202300068