Bacteriology of Different Phenotypes of Chronic Rhinosinusitis

• Published in: The Laryngoscope 2024-03, Vol.134 (3), p.1071-1076
• Main Authors: Li, Yu‐Ting, Huang, Shuang‐Shuang, Ma, Jia‐Hung, Hsieh, Bing‐Han, Tsou, Yung‐An, Lin, Chia‐Der, Tai, Chih‐Jaan, Shih, Liang‐Chun
• Format: Article
• Language: English
• Subjects: bacteriology; central compartment atopic disease; chronic rhinosinusitis; Economic impact; eosinophilic chronic rhinosinusitis; functional endoscopic sinus surgery; Staphylococcus infections
• ISSN: 0023-852X; 1531-4995; 1531-4995
• DOI: 10.1002/lary.30905

Objectives Chronic rhinosinusitis (CRS) reduces the health‐related quality of life and subsequently causes a tremendous socio‐economic impact. Although many studies have been conducted, few have identified a relationship between bacteriological characteristics and different phenotypes or endotypes. Therefore, this study aimed to elucidate the recent trends in bacterial cultures from different types of CRS in the Asian population. Methods This retrospective case–control study recruited patients diagnosed with CRS who underwent functional endoscopic sinus surgery (FESS) at a tertiary hospital in Taiwan. The patients were classified into those with chronic rhinosinusitis with nasal polyps (CRSwNP)/chronic rhinosinusitis without nasal polyps (CRSsNP), eosinophilic chronic rhinosinusitis (eCRS)/non‐eosinophilic chronic rhinosinusitis (NECRS), and central compartment atopic disease (CCAD)/lateral‐dominant nasal polyp (LDNP) groups. The demographic data and bacteriological characteristics of the groups were analyzed. Results We included 503 patients, identifying no significant difference between CRSwNP and CRSsNP for several common bacteria in CRS. The number of Staphylococcus epidermidis isolates in culture was significantly higher in the NECRS group (50.46% vs. 32.56%, p = 0.0003) than that in the eCRS group. The number of methicillin‐resistant Staphylococcus aureus (MRSA; 8.51% vs. 2.35%, p = 0.0221) positive isolates was significantly higher in the CCAD group than that in the LDNP group. Conclusions This was the first study in Asia to analyze the relationship between bacteriological characteristics and CCAD. MRSA is significantly higher in the CCAD group than that in the LDNP group. Recognizing the unique microbiology of CRSwNP, eCRS, and CCAD is crucial when selecting antimicrobial therapy to lessen the socio‐economic impact. Level of Evidence 3 Laryngoscope, 134:1071–1076, 2024