Rapid Screening of Urinary Tract Infection Using Microfluidic Inertial-Impedance Cytometry

Urinary tract infection (UTI) diagnosis based on urine culture for bacteriuria analysis is time-consuming and often leads to wastage of hospital resources due to false-positive UTI cases. Direct cellular phenotyping (e.g., RBCs, neutrophils, epithelial cells) of urine samples remains a technical cha...

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Bibliographic Details
Published in:ACS sensors 2023-08, Vol.8 (8), p.3136-3145
Main Authors: Petchakup, Chayakorn, Chen, Yuan Yi Constance, Tay, Hui Min, Ong, Hong Boon, Hon, Pei Yun, De, Partha Pratim, Yeo, Tsin Wen, Li, King Ho Holden, Vasoo, Shawn, Hou, Han Wei
Format: Article
Language:English
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Summary:Urinary tract infection (UTI) diagnosis based on urine culture for bacteriuria analysis is time-consuming and often leads to wastage of hospital resources due to false-positive UTI cases. Direct cellular phenotyping (e.g., RBCs, neutrophils, epithelial cells) of urine samples remains a technical challenge as low cell concentrations, and urine characteristics (conductivities, pH, microbes) can affect the accuracy of cell measurements. In this work, we report a microfluidic inertial-impedance cytometry technique for label-free rapid (
ISSN:2379-3694
2379-3694
DOI:10.1021/acssensors.3c00819