The role of sclerostin in lipid and glucose metabolism disorders

[Display omitted] Lipid and glucose metabolism are critical for human activities, and their disorders can cause diabetes and obesity, two prevalent metabolic diseases. Studies suggest that the bone involved in lipid and glucose metabolism is emerging as an endocrine organ that regulates systemic met...

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Published in:Biochemical pharmacology 2023-09, Vol.215, p.115694-115694, Article 115694
Main Authors: Jiang, Hewen, Li, Dijie, Han, Ying, Li, Nanxi, Tao, Xiaohui, Liu, Jin, Zhang, Zongkang, Yu, Yuanyuan, Wang, Luyao, Yu, Sifan, Zhang, Ning, Xiao, Huan, Yang, Xin, Zhang, Yihao, Zhang, Ge, Zhang, Bao-Ting
Format: Article
Language:English
Subjects:
Diabetes
Glucose metabolism
Lipid metabolism
Obesity
Sclerostin
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Summary:[Display omitted] Lipid and glucose metabolism are critical for human activities, and their disorders can cause diabetes and obesity, two prevalent metabolic diseases. Studies suggest that the bone involved in lipid and glucose metabolism is emerging as an endocrine organ that regulates systemic metabolism through bone-derived molecules. Sclerostin, a protein mainly produced by osteocytes, has been therapeutically targeted by antibodies for treating osteoporosis owing to its ability to inhibit bone formation. Moreover, recent evidence indicates that sclerostin plays a role in lipid and glucose metabolism disorders. Although the effects of sclerostin on bone have been extensively examined and reviewed, its effects on systemic metabolism have not yet been well summarized. In this paper, we provide a systemic review of the effects of sclerostin on lipid and glucose metabolism based on in vitro and in vivo evidence, summarize the research progress on sclerostin, and prospect its potential manipulation for obesity and diabetes treatment.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2023.115694