Oxidative Tandem Cyclization of Glycine Esters with Propargyl Alcohols

A facile and efficient aerobic oxidative (4 + 2)-cyclization/aromatization/lactonization tandem reaction of N-aryl glycine esters with propargyl alcohols to access quinoline-fused lactones is reported. The reaction can be extended to homopropargylic alcohols too. The transformation is straightforwar...

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Bibliographic Details
Published in:Journal of organic chemistry 2023-07, Vol.88 (14), p.10232-10241
Main Authors: Sang, Tongzhi, Liang, Jia, Huang, Songhai, Guo, Guozhe, Yang, Jie, Bao, Xiazhen, Huo, Congde
Format: Article
Language:English
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Summary:A facile and efficient aerobic oxidative (4 + 2)-cyclization/aromatization/lactonization tandem reaction of N-aryl glycine esters with propargyl alcohols to access quinoline-fused lactones is reported. The reaction can be extended to homopropargylic alcohols too. The transformation is straightforward to perform under mild conditions and scalable, and both reaction components are readily available.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c00627