Diuretic activity of Euphorbia serpens extracts in Wistar rats

Euphorbia serpens has been used in central-west region of Argentina in traditional medicine as diuretic plant. The aim of this present study was to evaluate the diuretic activity of E. serpens in-vivo. We used dried aerial parts, and infusions from these were orally administered to Wistar rats. Its...

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Bibliographic Details
Published in:Natural product research 2024-06, Vol.38 (12), p.2140-2144
Main Authors: Garro, María F., Gil, Raúl A., Leporati, Jorge, Garro, Hugo A.
Format: Article
Language:English
Subjects:
Animals
Argentina
Biocompatibility
diuretic activity
Diuretics
Diuretics - chemistry
Diuretics - pharmacology
Elaphoglossum serpens
Euphorbia
Euphorbia - chemistry
Euphorbia serpens
Furosemide
Furosemide - pharmacology
hederagenin
Male
Mannitol
Medicinal plants
Oleanolic Acid - analogs & derivatives
Oleanolic Acid - chemistry
Oleanolic Acid - pharmacology
Oral administration
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rats
Rats, Wistar
Saline solutions
sodium & potassium content in urine
Triterpenoids
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Summary:Euphorbia serpens has been used in central-west region of Argentina in traditional medicine as diuretic plant. The aim of this present study was to evaluate the diuretic activity of E. serpens in-vivo. We used dried aerial parts, and infusions from these were orally administered to Wistar rats. Its effect was evaluated using furosemide as a positive drug and isotonic salt solution as negative control. Their urine output was quantified at several time intervals. The volume of urine excreted and Na + increased significantly, being similar to furosemide. Mannitol, was the main component in aqueous extracts of E. serpens, and the acetone extract showed the presence of Δ 12 - oleanane-type triterpenoids compounds, mainly hederagenin. No toxic effects were observed.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2237171