Assessment of the genomic stability of calves obtained from artificial insemination and OPU/IVP in vitro fertilization

Damage to genetic material and errors in the functioning of cellular mechanisms disturb genome stability and integrity. Assessment of genomic stability in animals is a very important aspect of breeding work. Unfortunately, harmful instabilities affect the functioning, health and reproductive process...

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Bibliographic Details
Published in:Reproduction in domestic animals 2023-09, Vol.58 (9), p.1289-1297
Main Authors: Kępka, Katarzyna, Wójcik, Ewa, Wysokińska, Anna
Format: Article
Language:English
Subjects:
Animals
Artificial insemination
Biotechnology
Breeding
Damage
Fragile sites
Genomics
In vitro fertilization
Sister chromatid exchange
Stability analysis
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Summary:Damage to genetic material and errors in the functioning of cellular mechanisms disturb genome stability and integrity. Assessment of genomic stability in animals is a very important aspect of breeding work. Unfortunately, harmful instabilities affect the functioning, health and reproductive processes of animals. Obtaining healthy calves is a priority, whatever methods of reproductive biotechnology are applied. The aim of the study was to assess the genomic stability of calves obtained from artificial insemination and OPU/IVP in vitro fertilization. The genomic stability of the calves was evaluated using the comet, sister chromatid exchange, and fragile sites assays. Damage to the genetic material of calves obtained by two reproductive biotechnologies was identified. Identification of instability in animals can be a valuable tool in breeding work and accelerate breeding progress.
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.14433