Interactions of Mn complexes with DNA: the relevance of therapeutic applications towards cancer treatment

Manganese (Mn) is one of the most significant bio-metals that helps the body to form connective tissue, bones, blood clotting factors, and sex hormones. It is necessary for fat and carbohydrate metabolism, calcium absorption, blood sugar regulation, and normal brain and nerve functions. It accelerat...

Full description

Saved in:
Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2023-08, Vol.52 (31), p.1639-1656
Main Authors: Mallick Ganguly, Oishi, Moulik, Shuvojit
Format: Article
Language:English
Subjects:
Biological effects
Blood
Bones
Cancer
Carbohydrate metabolism
Carbohydrates
Clotting
Connective tissues
DNA
Free radicals
Fungicides
Glutamine
Hematopoiesis
Infectious diseases
Manganese
Manganese - metabolism
Metabolism
Neoplasms - drug therapy
Nuclease
Protein synthesis
Sex hormones
Superoxide dismutase
Superoxide Dismutase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Manganese (Mn) is one of the most significant bio-metals that helps the body to form connective tissue, bones, blood clotting factors, and sex hormones. It is necessary for fat and carbohydrate metabolism, calcium absorption, blood sugar regulation, and normal brain and nerve functions. It accelerates the synthesis of proteins, vitamin C, and vitamin B. It is also involved in the catalysis of hematopoiesis, regulation of the endocrine level, and improvement of immune function. Again, Mn metalloenzymes like arginase, glutamine synthetase, phosphoenolpyruvate decarboxylase, and Mn superoxide dismutase (MnSOD) contribute to the metabolism processes and reduce oxidative stress against free radicals. Recent investigations have revealed that synthetic Mn-complexes act as antibacterial and antifungal agents. As a result, chemists and biologists have been actively involved in developing Mn-based drugs for the treatment of various diseases including cancer. Therefore, any therapeutic drugs based on manganese complexes would be invaluable for the treatment of cancer/infectious diseases and could be a better substitute for cisplatin and other related platinum based chemotherapeutic drugs. From this perspective, attempts have been made to discuss the interactions and nuclease activities of Mn( ii / iii / iv ) complexes with DNA through which one can evaluate their therapeutic applications. Design of manganese-based drug conjugates for selective targeting of cancer cells will be a major breakthrough in the field of cancer research.
ISSN:1477-9226
1477-9234
DOI:10.1039/d3dt00659j