Highlights from the 1st European cancer dependency map symposium and workshop

The systematic identification of tumour vulnerabilities through perturbational experiments on cancer models, including genome editing and drug screens, is playing a crucial role in combating cancer. This collective effort is known as the Cancer Dependency Map (DepMap). The 1st European Cancer Depend...

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Bibliographic Details
Published in:FEBS letters 2023-08, Vol.597 (15), p.1921-1927
Main Authors: Trastulla, Lucia, Savino, Aurora, Beltrao, Pedro, Ciriano, Isidro Cortés, Fenici, Peter, Garnett, Mathew J., Guerini, Ilaria, Bigas, Nuria Lòpez, Mattaj, Iain, Petsalaki, Evangelia, Riva, Laura, Tape, Christopher J., Leeuwen, Jolanda Van, Sharma, Sumana, Vazquez, Francisca, Iorio, Francesco
Format: Article
Language:English
Subjects:
cancer
cancer models
computational biology
CRISPR
dependency map
drug discovery
large scale
screens
symposium
workshop
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Summary:The systematic identification of tumour vulnerabilities through perturbational experiments on cancer models, including genome editing and drug screens, is playing a crucial role in combating cancer. This collective effort is known as the Cancer Dependency Map (DepMap). The 1st European Cancer Dependency Map Symposium (EuroDepMap), held in Milan last May, featured talks, a roundtable discussion, and a poster session, showcasing the latest discoveries and future challenges related to the DepMap. The symposium aimed to facilitate interactions among participants across Europe, encourage idea exchange with leading experts, and present their work and future projects. Importantly, it sparked discussions on future endeavours, such as screening more complex cancer models and accounting for tumour evolution. The inaugural European Cancer Dependency Symposium took place in May at Human Technopole in Milan, Italy. It aimed to showcase recent advancements in cancer functional/pharmaco‐genomics and projects identifying genetic vulnerabilities in cancer (known as ‘Cancer Dependency Map’). The subsequent workshop served as a forum to discuss aspects of future Cancer Dependency Map projects, laying the foundation for coordinated European efforts.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.14699