Altered expression of endosomal Toll‐like receptors and HBeAg seropositivity may act synergistically towards the vertical transmission of HBV

• Published in: American journal of reproductive immunology (1989) 2023-08, Vol.90 (2), p.e13747-n/a
• Main Authors: Kalita, Simanta, Kalita, Manash Jyoti, Hazarika, Gautam, Das, Partha Pratim, Dutta, Kalpajit, Rudola, Tanya, Das, Panchanan, Talukdar, Anjan Jyoti, Dutta, Sangitanjan, Idris, Md. Ghaznavi, Kar, Premashis, Medhi, Subhash
• Format: Article
• Language: English
• Subjects: Cord blood; Correlation analysis; Deoxyribonucleic acid; DNA; Down-regulation; HBV; Hepatitis B; Hepatitis B e antigen; Immunological tolerance; MTCT; Peripheral blood; Risk factors; RT‐PCR; TLR; Vaccination
• ISSN: 1046-7408; 1600-0897
• DOI: 10.1111/aji.13747

Problem Hepatitis B is one of the leading causes of mortality in India. Despite the mass vaccination programme, the burden of the infection is still increasing due to its vertical transmission. Asymptomatic nature of hepatitis B virus (HBV) infection owing to immune tolerance among pregnant women is a major issue in this regard. Method of study As such, this study aims to investigate the potential role of altered Toll‐like receptor (TLR) expression (TLR‐3, 7 and 9) along with peripheral blood HBeAg status in attaining differential cord blood (CB) HBV DNA status. Result Expression analysis reveals an overall downregulation of expression with mean ± SD value 1.14 ± 1.05, 0.86 ± 0.5 and 0.71 ± 0.4 (TLR 3, 7 and 9, respectively) upon comparison with healthy women. Further stratification based on CB HBV DNA status; the downregulation of expression was found to be significantly (p