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Host and Pathogen-Directed Therapies against Microbial Infections Using Exosome- and Antimicrobial Peptide-derived Stem Cells with a Special look at Pulmonary Infections and Sepsis
Microbial diseases are a great threat to global health and cause considerable mortality and extensive economic losses each year. The medications for treating this group of diseases (antibiotics, antiviral, antifungal drugs, etc.) directly attack the pathogenic agents by recognizing the target molecu...
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| Published in: | Stem cell reviews and reports 2023-10, Vol.19 (7), p.2166-2191 |
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| cites | cdi_FETCH-LOGICAL-c375t-d7a3c3421f62e494f0a24f54f8712da089d64f93aebeec0d6d35f0ef0eae2ffc3 |
| container_end_page | 2191 |
| container_issue | 7 |
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| container_title | Stem cell reviews and reports |
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| creator | Moosazadeh Moghaddam, Mehrdad Fazel, Parvindokht Fallah, Arezoo Sedighian, Hamid Kachuei, Reza Behzadi, Elham Imani Fooladi, Abbas Ali |
| description | Microbial diseases are a great threat to global health and cause considerable mortality and extensive economic losses each year. The medications for treating this group of diseases (antibiotics, antiviral, antifungal drugs, etc.) directly attack the pathogenic agents by recognizing the target molecules. However, it is necessary to note that excessive use of any of these drugs can lead to an increase in microbial resistance and infectious diseases. New therapeutic methods have been studied recently using emerging drugs such as mesenchymal stem cell-derived exosomes (MSC-Exos) and antimicrobial peptides (AMPs), which act based on two completely different strategies against pathogens including Host-Directed Therapy (HDT) and Pathogen-Directed Therapy (PDT), respectively. In the PDT approach, AMPs interact directly with pathogens to interrupt their intrusion, survival, and proliferation. These drugs interact directly with the cell membrane or intracellular components of pathogens and cause the death of pathogens or inhibit their replication. The mechanism of action of MSC-Exos in HDT is based on immunomodulation and regulation, promotion of tissue regeneration, and reduced host toxicity. This review studies the potential of mesenchymal stem cell-derived exosomes/ATPs therapeutic properties against microbial infectious diseases especially pulmonary infections and sepsis.
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| doi_str_mv | 10.1007/s12015-023-10594-2 |
| format | article |
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Graphical Abstract</description><subject>Antibiotics</subject><subject>Antimicrobial peptides</subject><subject>Antiviral agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cell Biology</subject><subject>Cell membranes</subject><subject>Drug development</subject><subject>Drugs</subject><subject>Exosomes</subject><subject>Immunomodulation</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Lung diseases</subject><subject>Mesenchymal stem cells</subject><subject>Pathogens</subject><subject>Public health</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Sepsis</subject><subject>Stem Cells</subject><subject>Toxicity</subject><issn>2629-3269</issn><issn>2629-3277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kd9qFDEUhwdRbKl9AS8k4I03qfk3k5nLslZbqLiw7XXITk52U2eSMclUfS8fsNluXcULIZBAvvOdk_yq6jUlZ5QQ-T5RRmiNCeOYkroTmD2rjlnDOsyZlM8P56Y7qk5TuiOkoESUmpfVEZeiq6Vkx9Wvy5Ay0t6gpc7bsAGPP7gIfQaDbrYQ9eQgIb3Rzhfus-tjWDs9oCtvC-SCT-g2Ob9BFz9CCiPgR9e5z248sEuYsjOADUR3X7yrDCNawDAk9N3lLdJoNUG_I4cQviKd0XIexuB1_Pl3n514BVNy6VX1wuohwenTflLdfry4WVzi6y-frhbn17jnss7YSM17Lhi1DQPRCUs0E7YWtpWUGU3azjTCdlzDGqAnpjG8tgTK0sCs7flJ9W7vnWL4NkPKanSpL4NrD2FOirWCEy5o1xX07T_oXZijL9MVSsq6bVjLC8X2VPmalCJYNUU3lncqStQuVrWPVZWs1GOsipWiN0_qeT2COZT8DrEAfA-kcuU3EP_0_o_2ASMOsHM</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Moosazadeh Moghaddam, Mehrdad</creator><creator>Fazel, Parvindokht</creator><creator>Fallah, Arezoo</creator><creator>Sedighian, Hamid</creator><creator>Kachuei, Reza</creator><creator>Behzadi, Elham</creator><creator>Imani Fooladi, Abbas Ali</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7339-8257</orcidid></search><sort><creationdate>20231001</creationdate><title>Host and Pathogen-Directed Therapies against Microbial Infections Using Exosome- and Antimicrobial Peptide-derived Stem Cells with a Special look at Pulmonary Infections and Sepsis</title><author>Moosazadeh Moghaddam, Mehrdad ; 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| subjects | Antibiotics Antimicrobial peptides Antiviral agents Biomedical and Life Sciences Biomedical Engineering and Bioengineering Cell Biology Cell membranes Drug development Drugs Exosomes Immunomodulation Infections Infectious diseases Life Sciences Lung diseases Mesenchymal stem cells Pathogens Public health Regenerative Medicine/Tissue Engineering Sepsis Stem Cells Toxicity |
| title | Host and Pathogen-Directed Therapies against Microbial Infections Using Exosome- and Antimicrobial Peptide-derived Stem Cells with a Special look at Pulmonary Infections and Sepsis |
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