The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke

Growing evidence has proved that alterations in the gut microbiota have been linked to neurological disorders including stroke. Structural and functional disruption of the blood-brain barrier (BBB) is observed after stroke. In this context, there is pioneering evidence supporting that gut microbiota...

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Bibliographic Details
Published in:Molecular neurobiology 2024-12, Vol.61 (12), p.9735-9755
Main Authors: Zeng, Meiqin, Peng, Meichang, Liang, Jianhao, Sun, Haitao
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - microbiology
Blood-Brain Barrier - pathology
Brain research
Cell Biology
Endothelium
Gastrointestinal Microbiome - physiology
Homeostasis
Humans
Immune system
Intestinal microflora
Kinases
Laboratories
Leukocytes
Membranes
Metabolism
Microbiota
Neurobiology
Neurological diseases
Neurology
Neurosciences
Neurosurgery
Oxidative stress
Pathogenesis
Stroke
Stroke - microbiology
Structure-function relationships
Traumatic brain injury
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Summary:Growing evidence has proved that alterations in the gut microbiota have been linked to neurological disorders including stroke. Structural and functional disruption of the blood-brain barrier (BBB) is observed after stroke. In this context, there is pioneering evidence supporting that gut microbiota may be involved in the pathogenesis of stroke by regulating the BBB function. However, only a few experimental studies have been performed on stroke models to observe the BBB by altering the structure of gut microbiota, which warrant further exploration. Therefore, in order to provide a novel mechanism for stroke and highlight new insights into BBB modification as a stroke intervention, this review summarizes existing evidence of the relationship between gut microbiota and BBB integrity and discusses the mechanisms of gut microbiota on BBB dysfunction and its role in stroke.
ISSN:0893-7648
1559-1182
1559-1182
DOI:10.1007/s12035-023-03512-7