Later onset focal epilepsy with roots in childhood: Evidence from early learning difficulty and brain volumes in the Human Epilepsy Project

Visual assessment of magnetic resonance imaging (MRI) from the Human Epilepsy Project 1 (HEP1) found 18% of participants had atrophic brain changes relative to age without known etiology. Here, we identify the underlying factors related to brain volume differences in people with focal epilepsy enrol...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2023-10, Vol.64 (10), p.2761-2770
Main Authors: Pellinen, Jacob, Pardoe, Heath, Sillau, Stefan, Barnard, Sarah, French, Jacqueline, Knowlton, Robert, Lowenstein, Daniel, Cascino, Gregory D, Glynn, Simon, Jackson, Graeme, Szaflarski, Jerzy, Morrison, Chris, Meador, Kimford J, Kuzniecky, Ruben
Format: Article
Language:English
Subjects:
Age
Anatomy
Brain architecture
Children
Cognitive ability
Convulsions & seizures
EEG
Epilepsy
Learning disabilities
Magnetic resonance imaging
Neuroimaging
Population studies
Seizures
Semiotics
Temporal lobe
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Summary:Visual assessment of magnetic resonance imaging (MRI) from the Human Epilepsy Project 1 (HEP1) found 18% of participants had atrophic brain changes relative to age without known etiology. Here, we identify the underlying factors related to brain volume differences in people with focal epilepsy enrolled in HEP1. Enrollment data for participants with complete records and brain MRIs were analyzed, including 391 participants aged 12-60 years. HEP1 excluded developmental or cognitive delay with intelligence quotient
ISSN:0013-9580
1528-1167
DOI:10.1111/epi.17727