ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe

In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary phase, termed the chronological lifespan (CLS), is affected by various environmental factors and the corresponding gene activities. The ecl family genes were identified in the genomic region encoding non-codin...

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Published in:Molecular microbiology 2023-11, Vol.120 (5), p.645-657
Main Authors: Ohtsuka, Hokuto, Otsubo, Yoko, Shimasaki, Takafumi, Yamashita, Akira, Aiba, Hirofumi
Format: Article
Language:English
Subjects:
Autophagy
Cell Cycle
Cell differentiation
Environmental factors
Gene Expression Regulation, Fungal - genetics
Genes
Kinases
Life span
Longevity - genetics
Mechanistic Target of Rapamycin Complex 1 - metabolism
Proteins
Rapamycin
Regulatory mechanisms (biology)
Schizosaccharomyces - genetics
Schizosaccharomyces - metabolism
Schizosaccharomyces pombe
Schizosaccharomyces pombe Proteins - genetics
Schizosaccharomyces pombe Proteins - metabolism
Sex differentiation
Starvation
Stationary phase
TOR protein
Yeasts
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Summary:In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary phase, termed the chronological lifespan (CLS), is affected by various environmental factors and the corresponding gene activities. The ecl family genes were identified in the genomic region encoding non-coding RNA as positive regulators of CLS in S. pombe, and subsequently shown to encode relatively short proteins. Several studies revealed that ecl family genes respond to various nutritional starvation conditions via different mechanisms, and they are additionally involved in stress resistance, autophagy, sexual differentiation, and cell cycle control. Recent studies reported that Ecl family proteins strongly suppress target of rapamycin complex 1, which is a conserved eukaryotic nutrient-sensing kinase complex that also regulates longevity in a variety of organisms. In this review, we introduce the regulatory mechanisms of Ecl family proteins and discuss their emerging findings.
ISSN:0950-382X
1365-2958
DOI:10.1111/mmi.15134