How will I recognize you? Insights into endocytic cargo recognition in plants

The plasma membrane (PM) houses a wide variety of proteins, facilitating interactions between the cell and its surroundings. Perception of external stimuli leads to selective internalization of membrane proteins via endocytosis. A multitude of endocytic signals affect protein internalization; howeve...

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Bibliographic Details
Published in:Current opinion in plant biology 2023-10, Vol.75, p.102429-102429, Article 102429
Main Authors: De Meyer, Andreas, Grones, Peter, Van Damme, Daniel
Format: Article
Language:English
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Summary:The plasma membrane (PM) houses a wide variety of proteins, facilitating interactions between the cell and its surroundings. Perception of external stimuli leads to selective internalization of membrane proteins via endocytosis. A multitude of endocytic signals affect protein internalization; however, their coordination and the exact mechanism of their recognition still remain elusive. In this review, we summarized the up-to-date knowledge of different internalization signals in PM cargo proteins and their involvement during protein trafficking. •Multiple cargo recognition signals function in parallel for most cargo proteins.•Ubiquitination emerges as the most prominent cargo internalization signal in plant clathrin-mediated endocytosis.•Ubiquitination is independently recognized by several endocytic players.•Cargo ubiquitination is controlled by addition, chain length, and competition.
ISSN:1369-5266
1879-0356
DOI:10.1016/j.pbi.2023.102429