Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait

• Published in: Gut microbes 2023-12, Vol.15 (1), p.2235067-2235067
• Main Authors: Esteban-Torres, Maria, Ruiz, Lorena, Rossini, Valerio, Nally, Ken, van Sinderen, Douwe
• Format: Article
• Language: English
• Subjects: bacteria-host interactions; carbohydrate-active enzymes; colonization factors; commensal bacteria; glycogen metabolism; gut microbiota; microbiome; Review
• ISSN: 1949-0976; 1949-0984
• DOI: 10.1080/19490976.2023.2235067

The human gut microbiota is a key contributor to host metabolism and physiology, thereby impacting in various ways on host health. This complex microbial community has developed many metabolic strategies to colonize, persist and survive in the gastrointestinal environment. In this regard, intracellular glycogen accumulation has been associated with important physiological functions in several bacterial species, including gut commensals. However, the role of glycogen storage in shaping the composition and functionality of the gut microbiota offers a novel perspective in gut microbiome research. Here, we review what is known about the enzymatic machinery and regulation of glycogen metabolism in selected enteric bacteria, while we also discuss its potential impact on colonization and adaptation to the gastrointestinal tract. Furthermore, we survey the presence of such glycogen biosynthesis pathways in gut metagenomic data to highlight the relevance of this metabolic trait in enhancing survival in the highly competitive and dynamic gut ecosystem.