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A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%–2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence o...

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Bibliographic Details
Published in:Journal of medical virology 2023-08, Vol.95 (8), p.e28993-n/a
Main Authors: Briese, Thomas, Tokarz, Rafal, Bateman, Lucinda, Che, Xiaoyu, Guo, Cheng, Jain, Komal, Kapoor, Vishal, Levine, Susan, Hornig, Mady, Oleynik, Alexandra, Quan, Phenix‐Lan, Wong, Wai H., Williams, Brent L., Vernon, Suzanne D., Klimas, Nancy G., Peterson, Daniel L., Montoya, Jose G., Ian Lipkin, Walter
Format: Article
Language:English
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Summary:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%–2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence of viral nucleic acid in blood, feces, and saliva of patients with ME/CFS using polymerase chain reaction and high‐throughput sequencing. We found no consistent group‐specific differences other than a lower prevalence of anelloviruses in cases compared to healthy controls. Our findings suggest that future investigations into viral infections in ME/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.
ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.28993