A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%–2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence o...

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Published in:Journal of medical virology 2023-08, Vol.95 (8), p.e28993-n/a
Main Authors: Briese, Thomas, Tokarz, Rafal, Bateman, Lucinda, Che, Xiaoyu, Guo, Cheng, Jain, Komal, Kapoor, Vishal, Levine, Susan, Hornig, Mady, Oleynik, Alexandra, Quan, Phenix‐Lan, Wong, Wai H., Williams, Brent L., Vernon, Suzanne D., Klimas, Nancy G., Peterson, Daniel L., Montoya, Jose G., Ian Lipkin, Walter
Format: Article
Language:English
Subjects:
Blood
Chronic fatigue syndrome
Fatigue
Fatigue Syndrome, Chronic - epidemiology
Feces
Humans
Immune response
ME/CFS
myalgic encephalomyelitis
Nucleic acids
Polymerase chain reaction
Saliva
sequencing
Virology
Virome
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cited_by cdi_FETCH-LOGICAL-c3883-aa60ff2429ed867c8cd45180e301a341f2c4373393ee7d9b42753ec8a6333f9b3
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creator Briese, Thomas
Tokarz, Rafal
Bateman, Lucinda
Che, Xiaoyu
Guo, Cheng
Jain, Komal
Kapoor, Vishal
Levine, Susan
Hornig, Mady
Oleynik, Alexandra
Quan, Phenix‐Lan
Wong, Wai H.
Williams, Brent L.
Vernon, Suzanne D.
Klimas, Nancy G.
Peterson, Daniel L.
Montoya, Jose G.
Ian Lipkin, Walter
description Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%–2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence of viral nucleic acid in blood, feces, and saliva of patients with ME/CFS using polymerase chain reaction and high‐throughput sequencing. We found no consistent group‐specific differences other than a lower prevalence of anelloviruses in cases compared to healthy controls. Our findings suggest that future investigations into viral infections in ME/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.
doi_str_mv 10.1002/jmv.28993
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subjects Blood
Chronic fatigue syndrome
Fatigue
Fatigue Syndrome, Chronic - epidemiology
Feces
Humans
Immune response
ME/CFS
myalgic encephalomyelitis
Nucleic acids
Polymerase chain reaction
Saliva
sequencing
Virology
Virome
title A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome
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